SB525334 - CAS# 356559-20-1 60295 Virshup IH

Virshup IH

Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides

HCQ is also a potent inhibitor of TLR9

InChi: InChI=1S/C25H22N6

PubMed PMID: 23972441

SB525334 - CAS# 356559-20-1 60295 Virshup IHSB525334, CAS No. 356559 20 1, is a potent and selective inhibitor of the transforming growth factor beta1 (TGF beta1) receptor, activin receptor like kinase (ALK5). SB525334 inhibited ALK5 kinase activity with an IC(50) of 14. 3 nM and was approximately 4 fold less potent as an inhibitor of ALK4 (IC(50) = 58. 5 nM). SB 525334 was inactive as an inhibitor of ALK2, ALK3, and ALK6 (IC(50) > 10, 000 nM). In cell based assays, SB 525334 (1 microM) blocked