RGB-286638 free base Size:Solid 10 mg Trametinib specifically binds to and

Trametinib specifically binds to and inhibits MEK 1 and 2

Published 2017 Jun 27

Smiles: COC1=CC=C(C=C1)C1(CNC(=O)C2=CC=C(C=C2)NC(=O)C2=CC=CO2)CCOCC1

Nedocromil inhibits the release of histamine

stimulates periosteal bone formation in monkeys

RGB-286638 free base Size:Solid 10 mg Trametinib specifically binds to andRGB 286638 is a multitargeted cyclin dependent kinase inhibitor. RGB 286638 triggers P53 dependent and independent anti multiple myeloma activity through inhibition of transcriptional CDKs. GB 286638 treatment resulted in MM cytotoxicity in vitro associated with inhibition of MM tumor growth and prolonged survival in vivo. RGB 286638 displayed caspase dependent apoptosis in both wt p53 and mutant p53 cells that was closely associated with the