TGR5 Polyclonal Antibody, 100ul Centrifugal Filter The encoded protein may be

The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329)

It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation

The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking

and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death

which is a motif known to be involved in protein-protein interactions

TGR5 Polyclonal Antibody, 100ul Centrifugal Filter The encoded protein may beGPBAR1 encodes a member of the G protein coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.