DOC11 Polyclonal Antibody, 100ul Cell Culture Easy-grip design on both sides

Easy-grip design on both sides

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The protein lacks the cytoplasmic domain characteristic of other cadherins

most notably the t(9|22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR| MIM:151410)

thereby negatively regulating the activity of the DDX58 gene product

DOC11 Polyclonal Antibody, 100ul Cell Culture Easy-grip design on both sidesThe DHR 2 domain is necessary for the GEF activity.,Guanine nucleotide exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.,miscellaneous:'Zizim' means 'spike' in Hebrew.,PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the DOCK family.,Contains 1 DHR 1 (CZH 1) domain.,Contains 1 DHR 2 (CZH 2) domain.,Contains 1 PH domain.,subunit: Interacts with CDC42.,