Tuberin/TSC2(Phospho-Ser1387) Rabbit Polyclonal Antibody, 50ul Organelle Studies Cytoplasmic ribosomes

Cytoplasmic ribosomes

Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axon outgrowth

It contains a 5' CpG island that may be a frequent target of hypermethylation| and it may undergo hypermethylation-based silencing in some bladder cancers

It is heterogeneously expressed in the brain

ALK encodes a receptor tyrosine kinase

Tuberin/TSC2(Phospho-Ser1387) Rabbit Polyclonal Antibody, 50ul Organelle Studies Cytoplasmic ribosomesMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.