ZAP-70(Phospho Tyr292) Polyclonal Antibody, 100ul Culture Tubes The physiological role of this

The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption

It encodes a single-pass type I membrane protein with multiple cysteine rich domains| a transmembrane domain| a tyrosine kinase domain| a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif

this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins

and is thought to be important for interaction between T lymphocytes and endothelial cells

The other two isoforms| p52Shc and p46Shc| link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex

ZAP-70(Phospho Tyr292) Polyclonal Antibody, 100ul Culture Tubes The physiological role of thisThis gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T cell antigen receptor (TCR) stimulation, functions in the initial step of TCR mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene