Nibrin Polyclonal Antibody, 20ul[BT-AP06020] Recombinant Protein Expression Diseases associated with FAM117B include

Diseases associated with FAM117B include amyotrophic lateral sclerosis 2

interleukin 28A (IL28A)

at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme

blood clotting

The B cell antigen

Nibrin Polyclonal Antibody, 20ul[BT-AP06020] Recombinant Protein Expression Diseases associated with FAM117B includeMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.