Nkx-2.8 Polyclonal Antibody, 20ul Cell Culture The cytoplasmic peripheral membrane protein

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli

is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al

suggesting its role in diverse biochemical activities related to signal transduction

The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE)

a FAD-binding motif

Nkx-2.8 Polyclonal Antibody, 20ul Cell Culture The cytoplasmic peripheral membrane proteinThe protein encoded by this gene is a homeobox containing developmental regulator associated with liver development. The encoded protein binds to the alpha fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung