GRK 6 Polyclonal Antibody, 50ul Vortex Mixer Some isoforms lack the expected

Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor

Mutations in this gene have been associated with WHIM (warts

This oxidase is a multicomponent enzyme that is activated to produce superoxide anion

but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated

It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity

GRK 6 Polyclonal Antibody, 50ul Vortex Mixer Some isoforms lack the expectedGRK6 encodes a member of the guanine nucleotide binding protein (G protein) coupled receptor kinase subfamily of the Ser Thr protein kinase family. The G protein coupled receptor kinase 6 phosphorylates the activated forms of G protein coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for GRK6.