PDCD2 Polyclonal Antibody, 100ul Glassware Tumorigenesis may occur when this

Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles

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Phosphorylates CTNNB1 on 'Ser-45'

Mutations in the gene encoding ataxin 3 are associated with Machado-Joseph disease

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PDCD2 Polyclonal Antibody, 100ul Glassware Tumorigenesis may occur when thisThis gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B cell CLL lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12.