UIMC1 Polyclonal Antibody, 100ul Biochemical Reagents Aberrant expression of this gene

Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types

These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators

Biosealing: Yes

Forms a ternary complex with TRIM63 and PRKCE

and two tandem catalytic domains

UIMC1 Polyclonal Antibody, 100ul Biochemical Reagents Aberrant expression of this geneThis gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants.