CIR1A Rabbit Polyclonal Antibody, 50ul Vortex Mixer human hepatic leukemia factor (HLF)

human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP)

This gene is a putative tumor suppressor

The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes

Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression

This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation

CIR1A Rabbit Polyclonal Antibody, 50ul Vortex Mixer human hepatic leukemia factor (HLF)This gene encodes a WD40 repeat containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants.