MIA Polyclonal Antibody, 100ul[BT-AP05403] Gel & Buffers In nucleus

In nucleus

The nuclear form

Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094)

The encoded preproprotein is proteolytically processed to generate the mature protein

which incorporates synthetic genotyping (Synotype) alongside Genotype and Phenotype

MIA Polyclonal Antibody, 100ul[BT-AP05403] Gel & Buffers In nucleusThe product of CHD4 belongs to the SNF2 RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different