FEN-1 Polyclonal Antibody, 50ul Cell Culture Plates Alternatively spliced transcript variants have

Alternatively spliced transcript variants have been found in this gene

GO annotations related to this gene include dystroglycan binding

or designated sites specified by the customer

and in transport of secretory cargo from the endoplasmic reticulum

Also expressed in nonhematopoietic tissues such as heart and skeletal muscle

FEN-1 Polyclonal Antibody, 50ul Cell Culture Plates Alternatively spliced transcript variants haveFlap endonuclease 1 encoded by FEN1 removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG RAD2 endonuclease family and is