Dok-3 Polyclonal Antibody, 50ul General Lab Use Knockdown studies in zebrafish suggest

Knockdown studies in zebrafish suggest that this gene is essential for normal inner ear function

374 amino acids with all 11 kinase subdomains

Mutations in this gene are associated with megalencep

Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52

IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta

Dok-3 Polyclonal Antibody, 50ul General Lab Use Knockdown studies in zebrafish suggestDok 1, Dok 2 and Dok 3 are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok 1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Dok 2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr Abl. Dok 3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B