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EI2BE Polyclonal Antibody, 50ul Custom DNA Oligos The use of a non-canonical

SKU: 87148221178

4.2
PLN162.00 PLN195.00

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EI2BE Polyclonal Antibody, 50ul Custom DNA Oligos The use of a non-canonicalThis gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.

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Description

The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine

The encoded protein (sphingosine-1-phosphate receptor 2) is a receptor for sphingosine 1-phosphate

The encoded protein may be involved in endosome-to-Golgi transport

USP36 (ubiquitin specific peptidase 36) encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases

IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells

EI2BE Polyclonal Antibody, 50ul Custom DNA Oligos The use of a non-canonicalThis gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.

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