PCNA Monoclonal Antibody(12D10), 100ul Diagnostic Probes & Oligos NCK2 (NCK adaptor protein 2)

NCK2 (NCK adaptor protein 2) encodes a member of the NCK family of adaptor proteins

Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT)

form the stage selector protein(SSP) complex

interacts with 14-3-3 proteins

Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes

PCNA Monoclonal Antibody(12D10), 100ul Diagnostic Probes & Oligos NCK2 (NCK adaptor protein 2)The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6 dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have