Corticotropin-releasing factor receptor 2 Polyclonal Antibody, 20ul Reservoirs Mutations in this gene cause

Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex| leading to epilepsy| mental retardation| subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain&quo

Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores

The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns

|PTM:N- and O-glycosylated| phosphorylated and palmitoylated

gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS)

Corticotropin-releasing factor receptor 2 Polyclonal Antibody, 20ul Reservoirs Mutations in this gene causeThe protein encoded by this gene belongs to the G protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies