GRK2(Phospho-Tyr86) Polyclonal Antibody, 50ul Immuno Plates |enzyme regulation:Cannot be activated without

|enzyme regulation:Cannot be activated without removal of the activation peptide

based on sequence identity to its mouse counterpart

Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains

The integrin subunit beta 2 plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency

GRK2(Phospho-Tyr86) Polyclonal Antibody, 50ul Immuno Plates |enzyme regulation:Cannot be activated withoutThe product of this gene phosphorylates the beta 2 adrenergic receptor and appears to mediate agonist specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G protein coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.