IGF-IR Polyclonal Antibody, 20ul[BT-AP04398] Custom Peptide Synthesis and mutations in it have

and mutations in it have been associated with malignant rhabdoid tumors

also known as TOME1 (Trigger of mitotic entry protein 1) and GRCC8 (Gene-rich cluster protein C8)

These transcription factors share a leucine zipper region that is involved in protein-protein interactions

Among its related pathways are Metabolism of proteins and O-linked glycosylation

There is a pseudogene for BCL2L12 on chromosome 3

IGF-IR Polyclonal Antibody, 20ul[BT-AP04398] Custom Peptide Synthesis and mutations in it haveIGF1R, this receptor binds insulin like growth factor with a high affinity. It has tyrosine kinase activity. The insulin like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms