DNA Ligase IV(Phospho Thr650) Polyclonal Antibody, 100ul Custom Peptide Synthesis Its cleavage by caspases is

Its cleavage by caspases is required to induce apoptosis

tissue specificity:Weakly expressed in a few tissues

The encoded protein is a cytokine produced in response to viral infection

which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway

It may play a role in signal transduction cascades in terminally differentiated cells

DNA Ligase IV(Phospho Thr650) Polyclonal Antibody, 100ul Custom Peptide Synthesis Its cleavage by caspases isThe protein encoded by this gene is a DNA ligase that joins single strand breaks in a double stranded polydeoxynucleotide in an ATP dependent reaction. This protein is essential for V(D)J recombination and DNA double strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA dependent protein kinase (DNA PK). Both XRCC4