IRP-1(Phospho Ser711) Polyclonal Antibody, 20ul ADME including embryogenesis

including embryogenesis

Pseudogenes of this gene are located on the long arms of chromosomes 8| 10 and 12

Multiple transcript variants encoding different isoforms have been found for EIF2B4

and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093)

The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins

IRP-1(Phospho Ser711) Polyclonal Antibody, 20ul ADME including embryogenesisThe protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe 4S cluster and functions as an aconitase. Aconitases are iron sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds