DSE Rabbit Polyclonal Antibody, 100ul Centrifuges The protein encoded by LEPR

The protein encoded by LEPR belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins

Alternative splicing of this gene generates 2 transcript variants| but the full length nature of one of the variants has not been defined

down-regulated by phorbol 12-myristate 13-acetate

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Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes

DSE Rabbit Polyclonal Antibody, 100ul Centrifuges The protein encoded by LEPRThe protein encoded by this gene is a tumor rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D glucuronic acid to L iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA A24 restricted and tumor specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural