SIX3 Polyclonal Antibody, 50ul Purification DUSP14 contains the consensus DUSP

DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al

The tyrosine kinase non receptor 2 may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway

Inhibits CREB activity by phosphorylating and repressing TORCs

The protein encoded by this gene belongs to the SMAD family of proteins

Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17

SIX3 Polyclonal Antibody, 50ul Purification DUSP14 contains the consensus DUSPThis gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2.