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IP3R-I Polyclonal Antibody, 100ul[BT-AP04603] Dry Bath A group of proteins that

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IP3R-I Polyclonal Antibody, 100ul[BT-AP04603] Dry Bath A group of proteins thatITPR1 (inositol 1,4,5 trisphosphate receptor type 1) encodes an intracellular receptor for inositol 1,4,5 trisphosphate. Upon stimulation by inositol 1,4,5 trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for ITPR1.

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Description

A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases

found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013)

Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent

including those involved in energy metabolism

NBPF5 (neuroblastoma breakpoint family member 5) is a 351 amino acid cytoplasmic protein that is expressed in medulla and brain and belongs to the NBPF family

IP3R-I Polyclonal Antibody, 100ul[BT-AP04603] Dry Bath A group of proteins thatITPR1 (inositol 1,4,5 trisphosphate receptor type 1) encodes an intracellular receptor for inositol 1,4,5 trisphosphate. Upon stimulation by inositol 1,4,5 trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for ITPR1.

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