PRAF3 Rabbit Polyclonal Antibody, 100ul Reservoirs SIAH2 encodes E3 ubiquitin-protein ligase

SIAH2 encodes E3 ubiquitin-protein ligase SIAH2 that is a member of the seven in absentia homolog (SIAH) family

A full-length representative protein consists of an extracellular region| composed of three immunoglobulin-like domains| a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain

The chaperonin containing TCP1 subunit 5 encoded by CCT5 is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT)

Alternate splicing results in three transcript variants

and have been shown to be overexpressed in a variety of human cancers

PRAF3 Rabbit Polyclonal Antibody, 100ul Reservoirs SIAH2 encodes E3 ubiquitin-protein ligaseExpression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid which results in a specific reduction in EAAC1 mediated glutamate transport.