Huntingtin(Phospho Ser421) Polyclonal Antibody, 20ul Custom RNA Oligos The encoded protein is linked

The encoded protein is linked with a ubiquitin-like protein| NEDD8| which can be conjugated to cellular proteins| such as Cdc53/culin

The encoded protein catalyzes the dephosphorylation of phosphotyrosine and phosphatidylinositol and plays roles in cellular proliferation and differentiation

It is localized in nuclear bodies of the nucleus

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Huntingtin(Phospho Ser421) Polyclonal Antibody, 20ul Custom RNA Oligos The encoded protein is linkedHuntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9 35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as