Raf-1 Polyclonal Antibody, 100ul[BT-AP13531] Drug Development and Evaluation disease:Defects in COL2A1 are a

disease:Defects in COL2A1 are a cause of primary avascular necrosis of femoral head (ANFH)

The protein encoded by this gene belongs to the iodothyronine deiodinase family

The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity

The TRIM family is characterized by a signature motif composed of a RING finger| one or more B-box domains| and a coiled-coil region

Specific isoforms bind to alpha-dystroglycan and to alpha-latroxin

Raf-1 Polyclonal Antibody, 100ul[BT-AP13531] Drug Development and Evaluation disease:Defects in COL2A1 are aThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.