GRP78/Bip Monoclonal Antibody(10C9), 100ul Low retention tips Deacetylation by SIRT1 is NAD-dependent

Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity

This gene encodes the human homolog of yeast class C Vps18 protein

It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expre

and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34

The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal| followed by two fibronectin type-III motifs

GRP78/Bip Monoclonal Antibody(10C9), 100ul Low retention tips Deacetylation by SIRT1 is NAD-dependentThe protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.