PARP8 Polyclonal Antibody, 20ul Gloves The protein encoded by this

The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit

They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes

This gene and two other related trefoil family member genes are found in a cluster on chromosome 21

Subfamily A contains 12 genes| subfamily B contains 7 genes and 2 pseudogenes| and the more distantly related subfamily C contains 3 genes

An important paralog of this gene is MID1

PARP8 Polyclonal Antibody, 20ul Gloves The protein encoded by thisCatalytic activity: NAD(+) + (ADP D ribosyl)(n) acceptor = nicotinamide + (ADP D ribosyl)(n+1) acceptor.,PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Contaminating sequence. Potential poly A sequence.,Contains 1 PARP catalytic domain.,