PYK2 Polyclonal Antibody, 50ul[BT-AP07520] Microplate Mixer Mutations in this gene have

Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome

also named as C21orf108

and are upregulated in psoriasis

Some Bartter-like syndromes result from defects in this gene

The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins

PYK2 Polyclonal Antibody, 50ul[BT-AP07520] Microplate Mixer Mutations in this gene havePTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and