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EMR2 Polyclonal Antibody, 50ul[BT-AP02942] Lysosome A variation in the last

SKU: 71846495270

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EMR2 Polyclonal Antibody, 50ul[BT-AP02942] Lysosome A variation in the lastADGRE2 encodes a member of the class B seven span transmembrane (TM7) subfamily of G protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N terminal epidermal growth factor like domains coupled to a TM7 domain via a mucin like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell cell adhesion through interaction with chondroitin sulfate

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Description

A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus

This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity

The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells

a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth

It was reported to have phosphorylation-dependent DNA-primase activity

EMR2 Polyclonal Antibody, 50ul[BT-AP02942] Lysosome A variation in the lastADGRE2 encodes a member of the class B seven span transmembrane (TM7) subfamily of G protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N terminal epidermal growth factor like domains coupled to a TM7 domain via a mucin like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell cell adhesion through interaction with chondroitin sulfate

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