PLEK2 Rabbit Polyclonal Antibody, 100ul Roller Bottles Mutations in this gene cause

Mutations in this gene cause Schwartz-Jampel syndrome type 2

including gene expression

Mutations in PRKAR1A cause Carney complex (CNC)

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Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones

PLEK2 Rabbit Polyclonal Antibody, 100ul Roller Bottles Mutations in this gene causeThe protein encoded by this gene associates with membrane bound phosphatidylinositols generated by phosphatidylinositol 3 kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1 q subcomponent B chain (C1QB) this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease.