T2R50 Polyclonal Antibody, 100ul Transporters Rho GEFs regulate the activity

Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis

The gene is ubiquitously expressed but is found in abundance in the spleen

Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and

Mutations in this gene have been associated with obesity and pituitary dysfunction

They are thought to play roles in acyl-CoA dependent lipid metabolism

T2R50 Polyclonal Antibody, 100ul Transporters Rho GEFs regulate the activityTAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein coupled second messenger pathway (Conte et al., 2002