AP2M1(Phospho-Thr156) Rabbit Polyclonal Antibody, 50ul Serological Pipets SIAH2 encodes E3 ubiquitin-protein ligase

SIAH2 encodes E3 ubiquitin-protein ligase SIAH2 that is a member of the seven in absentia homolog (SIAH) family

at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme

which contain multiple tyrosine residues and putative SH2 binding sites

and contraction

The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist

AP2M1(Phospho-Thr156) Rabbit Polyclonal Antibody, 50ul Serological Pipets SIAH2 encodes E3 ubiquitin-protein ligaseThis gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA 4 protein.