PEX14 Polyclonal Antibody, 100ul 3D Culture Contains 4 copies of a

Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM)

This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers

The gene was shown to be expressed primarily in brain and liver| and at a lower level in heart and stomach

and is involved in the regulation of immune and inflammatory responses

It also interacts with and is phosphoryated by serine/threonine kinase 25

PEX14 Polyclonal Antibody, 100ul 3D Culture Contains 4 copies of aThis gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.