GPR143 Polyclonal Antibody, 20ul Custom DNA Oligos The lack of detectable membrane

The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs

The encoded protein (cathepsin H)

and leads to apoptosis

The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation

CCDC102A (Coiled-Coil Domain Containing 102A) is a Protein Coding gene

GPR143 Polyclonal Antibody, 20ul Custom DNA Oligos The lack of detectable membraneGPR143 encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in GPR143 cause ocular albinism type 1, also referred to as Nettleship Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y.