Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 100ul Lysosome Two chains of the factor

Two chains of the factor are held together by 1 or more disulfide bonds

It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family

and so is not thought to be a cell-cell adhesion glycoprotein

The secreted protein acidic and cysteine rich is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape

which may mediate insulin signals to the actin cytoskeleton

Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 100ul Lysosome Two chains of the factorAlpha chains of type IV collagen have a non collagenous domain (NC1) at their C terminus frequent interruptions of the G X Y repeats in the long central triple helical domain (which may cause flexibility in the triple helix) and a short N terminal triple helical 7S domain. Type IV collagen is the major structural component of glomerular basement membranes (GBM) forming a 'chicken wire' meshwork together with laminins proteoglycans and entactin