SIN1 Rabbit Polyclonal Antibody, 50ul Drying & Desiccation inhibits VAV1 activation upon TCR

inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production

Mutations in this gene may be linked to chronic pancreatitis

It has Catalytic activity for class I and II ArfGAPs in vitro

Yeast two-hybrid studies found ULK1/2 associated with modulators of the endocytic pathway

A portion of the 3' untranslated region was used to map this gene to chromosome 21q21

SIN1 Rabbit Polyclonal Antibody, 50ul Drying & Desiccation inhibits VAV1 activation upon TCRThis gene encodes a protein that is highly similar to the yeast SIN1 protein a stress activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.