Syk Polyclonal Antibody, 50ul[BT-AP08702] Bio-Reaction Tube Alternative splicing results in multiple

Alternative splicing results in multiple transcript variants encoding different protein isoforms

A chromosomal translocation and gene fusion between this gene and zinc finger| MIZ-type containing 1 (Gene ID: 57178) may underlie intellectual disability and neuropsychiatric problems in a human patient

The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells

Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process

Mutations in this gene have been associated with microphthalmia

Syk Polyclonal Antibody, 50ul[BT-AP08702] Bio-Reaction Tube Alternative splicing results in multipleSYK encodes a member of the family of non receptor type Tyr protein kinases. Tyrosine protein kinase SYK is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas.