PUS10 Rabbit Polyclonal Antibody, 50ul Stepper The soluble isoforms are associated

The soluble isoforms are associated with the onset of pre-eclampsia

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC)

This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor

120 amino acid motif called the RGS domain

most of which utilize a serine nucleophile to form the G-X-S-X-G nucleophile elbow

PUS10 Rabbit Polyclonal Antibody, 50ul Stepper The soluble isoforms are associatedPseudouridination the isomerization of uridine to pseudouridine is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases such as PUS10 catalyze pseudouridination of structural RNAs including transfer ribosomal and splicing RNAs. These enzymes also act as RNA chaperones facilitating the correct folding and assembly of tRNAs (McCleverty