A20 Polyclonal Antibody, 100ul[BT-AP00064] Mechanical Pipette Binding of these ligands to

Binding of these ligands to the receptor activates several signal transduction pathways

Members of PAX8 family typically encode proteins that contain a paired box domain

Contains 4 ANK repeats

Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases

were discovered as mammalian homologs of the C

A20 Polyclonal Antibody, 100ul[BT-AP00064] Mechanical Pipette Binding of these ligands toTNFAIP3 was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). TNF alpha induced protein 3 encoded by TNFAIP3 is a zinc finger protein and ubiqitin editing enzyme, and has been shown to inhibit NF kappa B activation as well as TNF mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine mediated immune and inflammatory responses.