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may play a role in neuromuscular synaptic transmission

a major controlling element of neutrophil elastase activity

and it also acts as a tumor suppressor

The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg)| a macromolecular precursor in thyroid hormone synthesis| while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg

LETM1 Rabbit Polyclonal Antibody, 100ul Purification Push the boundaries and elevateThis gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf Hirschhorn syndrome a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8 15 and 19.