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RNase Z2 Polyclonal Antibody, 50ul Drug Development and Evaluation Mutations in BRCA1 are responsible

SKU: 57045092779

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RNase Z2 Polyclonal Antibody, 50ul Drug Development and Evaluation Mutations in BRCA1 are responsibleThe protein encoded by ELAC2 (elaC ribonuclease Z 2) has a C terminal domain with tRNA processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST 1), and reduced expression can suppress transforming growth factor beta induced growth arrest. Mutations in ELAC2 result in an

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Description

Mutations in BRCA1 are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers

The alpha subunit includes the skeletal muscle and hepatic isoforms

also known as F-actin bundling domain

ghrelin and obestatin

There is a DQHA (X)2E (X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease

RNase Z2 Polyclonal Antibody, 50ul Drug Development and Evaluation Mutations in BRCA1 are responsibleThe protein encoded by ELAC2 (elaC ribonuclease Z 2) has a C terminal domain with tRNA processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST 1), and reduced expression can suppress transforming growth factor beta induced growth arrest. Mutations in ELAC2 result in an

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