KLHL13 Monoclonal Antibody, 100ul Aspirating Pipets The protein localizes to nuclear

The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors

providing high transparency that facilitates easy observation

The gene is deleted in Williams-Beuren syndrome| a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11

which leads to lighter skin and hair color

Mutations in this gene may result in Netherton syndrome

KLHL13 Monoclonal Antibody, 100ul Aspirating Pipets The protein localizes to nuclearThis gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3 based E3 ubiquitin protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants.