PPR1A Polyclonal Antibody, 50ul Supplements Mice deficient for this gene

Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure

Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin

This gene is part of the family of Rho guanine nucleotide exchange factors

The isoform type 3 can inhibit the function of isoforms type

but causes G2-M arrest in p53-null or –mutant cells

PPR1A Polyclonal Antibody, 50ul Supplements Mice deficient for this geneInhibitor of protein phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I 1 activity in many tissues. I 1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I 1 is inactivated by calcineurin (or PP2B). Does not inhibit type 2 phosphatases.,PTM: Phosphorylation of Thr 35 is