TTR mouse Monoclonal Antibody(9B5), 50ul sgRNA Library Construction is a E3 ubiquitin-protein ligase

is a E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage

Found in a complex with DNMT3A and HDAC7

Contains 4 C2H2-type zinc fingers

GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity

It may be a component of a prelamin A endoprotease complex

TTR mouse Monoclonal Antibody(9B5), 50ul sgRNA Library Construction is a E3 ubiquitin-protein ligaseThis gene encodes transthyretin, one of the three prealbumins including alpha 1 antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported most mutations are related to amyloid