Human Macrophage Inflammatory Protein-3Α, MIP-3A ELISA Kit , 96T ADME Disruption of CBX2 in mice

Disruption of CBX2 in mice results in male-to-female gonadal sex reversal

It is a costimulator of DNA-synthesis

The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor

a metalloproteinase domain

These receptors are members of the G protein-coupled receptor superfamily

Human Macrophage Inflammatory Protein-3Α, MIP-3A ELISA Kit , 96T ADME Disruption of CBX2 in miceActs as a ligand for C C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed: 11352563, PubMed: 11035086, PubMed: 20068036). The ligand receptor pair CCL20 CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector memory T cells and B cells and plays an important role at skin and mucosal surfaces under homeostatic and