Pax-9 Polyclonal Antibody, 50ul Bio-Reaction Tube TOP2B encoding this enzyme functions

TOP2B encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in TOP2B have been associated with the development of drug resistance

The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers

Although this gene was isolated as a transforming gene from a melanoma cell line

characterized by the lack of both the A and B subunits

Through its ability to signal initiation of the last step of vertebrate cytokinesis

Pax-9 Polyclonal Antibody, 50ul Bio-Reaction Tube TOP2B encoding this enzyme functionsPAX9 is a member of the paired box (PAX) family of transcription factors. Members of PAX9 family typically contain a paired box domain, an octapeptide, and a paired type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking PAX9 exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are