RPGF6 Polyclonal Antibody, 20ul Custom Peptide Synthesis ASPP proteins are required for

ASPP proteins are required for the induction of apoptosis by p53-family proteins

which is then further processed to generate numerous peptide products

The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation

including hereditary cancers such as Li-Fraumeni syndrome

The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules

RPGF6 Polyclonal Antibody, 20ul Custom Peptide Synthesis ASPP proteins are required forGuanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M Ras GTPases. Does not interact with cAMP.,PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.,Contains 1 cyclic nucleotide binding domain.,Contains 1 N terminal Ras GEF domain.,Contains 1 PDZ (DHR) domain.,Contains 1 Ras associating domain.,Contains 1 Ras GEF domain.,subcellular location: Upon binding to M Ras, it translocates to the plasma membrane.,subunit: Interacts with the